Upgrade of cGMP Production Facility

Open Closing: 6 May 2026 at 11:00 Published: 31 Mar 2026

Overview

Summary

This tender seeks a service provider to design and upgrade an existing Grade C production facility to a cGMP compliant Grade B facility. The project includes layout modifications, HVAC system upgrades, and adherence to stringent regulatory requirements.

Detailed Description

The South African Nuclear Energy Corporation is inviting bids for the upgrade of its P2000 Production Facility, transforming it from a Grade C to a cGMP compliant Grade B environment. This upgrade is essential for the aseptic manufacturing of fluorine-based radiopharmaceuticals, ensuring compliance with current Good Manufacturing Practices (cGMP) and enhancing operational efficiency. Key requirements include redesigning the facility layout to improve personnel and material flow, upgrading the HVAC system for optimal air quality, and ensuring all modifications meet regulatory standards.

The scope of work encompasses a comprehensive assessment of the existing facility, followed by the implementation of necessary upgrades. This includes the installation of new equipment, adherence to strict safety and health regulations, and the integration of advanced technologies to ensure the facility operates at peak efficiency. The successful bidder will play a crucial role in ensuring that the upgraded facility meets all operational needs while maintaining compliance with national and international standards, thereby enhancing the safety and quality of radiopharmaceutical production.

Suitable Businesses

This tender is suitable for construction firms, engineering service providers, and specialized contractors with experience in pharmaceutical facility upgrades, particularly those familiar with cGMP compliance and HVAC systems.

Documents

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